Introduction: Suicide is a major concern in Guyana with some regions including Region 3, recognized as particularly vulnerable for younger persons for suicidal attempts and completed suicides. Methods: Patients referred for psychiatric assessment over three months at the region’s major hospital were analyzed for factors associated with the attempts. Results: Over the three-month study period, 31 patients were seen on different wards of the hospital with the majority from the medical wards (n=28) surgical (n=3). The majority were female n=22 (70%). The age group 19 to 30 yrs (51%) also comprised most of the patients seen along with patients in the age group of 13 to 18 yrs. (43%). Five deaths occurred, 2 females and 3 males, who had all ingested gramoxone over the study period. The major factor for all suicide attempts was relationship conflict with a partner (78 %). Alcohol was implicated in the majority of the male patients (87%) including 2 males who accidentally ingested herbicides when under the influence. Significantly the absence of a father was notable in the majority of cases (90%), either by separation from the family or being absent because of being frequently intoxicated with alcohol. Ingestion of poison was the most frequent method of suicide attempt (80%), followed by ingestion of tablets. There was one case of attempted self-stabbing and one of attempted hanging. In all cases of ingestion of a poison, there was easy access to poison in the home. A significant number of patients (93%) were experiencing financial difficulties and were from the lower socio-economic group. More patients (38%) were from the village of Zeelugt followed by Parika (19%.) The outcome of therapy was good with readmission of only one patient, who has a history of multiple attempts and suffers from a borderline personality disorder. Conclusion: Suicide attempts occur at the alarming rate of one in every three days, mostly among young adult females and mostly linked to relationship difficulties.