Introduction: Suicide in young people, as well as older adults, is a global public health concern and it impacts third-world countries like Guyana. Suicide was the leading cause of death in low to middle-income countries, and Sri Lanka and Guyana had the highest rates of suicide(World Health Organization, 2017, World Atlas, 2017). Purpose: The purpose of this study was to examine which sociodemographic factors (age, gender, occupation, method of suicide, and region) are associated with suicide and method of suicide among people aged ≥ 15 years in Guyana. Also, because studies show that culture plays a pivotal role in suicide, this study investigated if there is a link between culture (ethnicity/race and religion) and suicide cases in this population in Guyana. Methods: This study used a quantitative cross-sectional design in order to quantify the problem of suicide in the ≥ 15 years population in Guyana. The socioecological model provided the framework for this quantitative study which used the 2015 cross-sectional secondary data from the Guyana Ministry of Public Health. Results: Bivariate analysis revealed that sociodemographic and cultural factors were significantly associated with suicide cases in Guyana, with men, aged 23-48 years old,
employed individuals, East Indians and Hindus having the higher suicide proportions. In addition, regression analysis indicated that men were 3.1 times more likely to commit suicide by hanging instead of drinking poison compared to females (OR: 3.1, 95%CI: 1.5- 6.7, p < 0.004). Conclusion: The positive social change implications include the identification of socioeconomic and cultural factors that are associated with suicide. These factors can be used to provide counseling sessions for persons who have suicidal behaviors and to adopt a collaborative approach by the World Health Organization, governmental, nongovernmental organizations, and civil society to reduce its prevalence.